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Updated: Jul 16, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: June 30, 2013
Association between apolipoprotein E genotypes and cancer risk in patients with acquired immunodeficiency syndrome
K Liestøl1, E A Kvittingen, H Rootwelt
1Department of Informatics, University of Oslo, Norway.
Abstract:
The apolipoprotein E (apoE) genotype was determined in 197 deceased acquired immunodeficiency syndrome (AIDS) patients treated at Ullevaal Hospital in Oslo, Norway. A full autopsy had been performed on all. Cancer had developed in 71 individuals, mainly lymphomas (46) and Kaposi's sarcomas (18). The apoE genotype distribution was consistent with Hardy-Weinberg equilibrium, and allele frequencies were in the typical Scandinavian range (6.9% apoE2; 75.6% apoE3; and 17.5% apoE4). Cancer cases had a significantly higher frequency of apoE4 alleles than noncancer cases (24.6% and 13.5%, respectively) and a lower frequency of apoE2 alleles (3.5% versus 8.7%). Background factors, such as survival from AIDS diagnosis, could not explain these differences. Our study thus indicates that apoE genotype affects the development of cancers among AIDS patients.
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