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Related Experiment Videos

Mefloquine-induced acute hepatitis.

I Gotsman1, T Azaz-Livshits, Z Fridlender

  • 1Department of Medicine, Hadassah University Hospital, Hebrew University, Hadassah Medical School, Jerusalem, Israel.

Pharmacotherapy
|December 29, 2000
PubMed
Summary

Mefloquine is an effective malaria drug, but can cause liver issues. Patients with existing liver problems should use mefloquine cautiously due to potential transaminase elevation.

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Area of Science:

  • Pharmacology
  • Hepatology
  • Infectious Diseases

Background:

  • Mefloquine is a widely used antimalarial medication effective against Plasmodium falciparum.
  • It is generally well-tolerated, with rare instances of elevated liver function tests reported.
  • Susceptible individuals with pre-existing liver abnormalities may be at higher risk.

Observation:

  • A patient with elevated liver transaminases, initially attributed to heart failure, was prescribed mefloquine.
  • Six weeks after commencing mefloquine 250 mg weekly, the patient experienced an acute increase in liver transaminases.
  • Discontinuation of mefloquine led to the normalization of liver function tests.

Findings:

  • Mefloquine exposure can lead to acute elevation of liver transaminases, particularly in patients with underlying liver conditions.

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  • The observed hepatotoxicity was reversible upon cessation of the drug.
  • This case highlights a potential adverse effect of mefloquine on liver function.

    • Implications:

    • Mefloquine should be prescribed with caution in patients diagnosed with liver disease.
    • Further investigation into mefloquine's hepatotoxic potential in vulnerable populations is warranted.
    • Clinicians should monitor liver function tests in patients with liver disease receiving mefloquine prophylaxis or treatment.