Randomised clinical trials in the Scandinavian Journal of Rheumatology

Area of Science:

• Medical research methodology
• Clinical trial reporting standards

Background:

• Accurate indexing of clinical trials is crucial for evidence-based medicine.
• Previous studies have suggested underreporting of randomized controlled trials in major databases.

Purpose of the Study:

• To identify all reports of randomized clinical trials published in the Scandinavian Journal of Rheumatology.
• To compare the handsearched findings with trial reports indexed in Medline.

Main Methods:

• A comprehensive handsearch of the Scandinavian Journal of Rheumatology, including supplements, from 1955 to 1997.
• Identification of randomized clinical trials and controlled clinical trials.

Main Results:

• A total of 445 trial reports were identified through handsearching.
• Only 134 trials (30%) were indexed as randomized or controlled trials in Medline.
• A substantial number of identified trials (59%) were not indexed in Medline, with many appearing in journal supplements.

Conclusions:

• Manual searching of medical journals for randomized trials is a valuable endeavor.
• Improved indexing practices can enhance the visibility of clinical trial research.
• Better access to trial data can inform clinical decisions and prevent redundant research.