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Optimization of a somatostatin mimetic via constrained amino acid and backbone incorporation

A J Souers1, A Rosenquist, E M Jarvie

  • 1Department of Chemistry, University of California, Berkeley 94720, USA.

Bioorganic & Medicinal Chemistry Letters
|January 2, 2001
PubMed

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Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally analyses the...