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Protein phosphatase 5 in signal transduction
1Dept of Pharmacology, University of South Alabama, Mobile, AL 36688, USA. michaelc@jaguar1.usouthal.edu
Trends in Endocrinology and Metabolism: TEM
|January 4, 2001
Abstract:
Protein phosphatase 5 (PP5) possesses unique biochemical properties, which include its tetratricopeptide repeat (TPR) targeting/regulatory domain and its ability to be activated by lipids. PP5 has been studied as a paradigm for TPR protein structure and function. Roles for PP5 in signal transduction are emerging: from cell cycle regulation and signaling by nuclear receptors, to possible regulation of membrane receptors and ion channels.