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Hormonal changes associated with Danazol therapy.

G P Wood, C H Wu, G L Flickinger

    Obstetrics and Gynecology
    |March 1, 1975
    PubMed
    Summary
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    Danazol treatment for endometriosis suppressed estradiol and progesterone to low levels, mimicking the follicular phase, while maintaining normal LH and low-normal FSH. Hormonal profiles returned to normal post-treatment, indicating reversible effects on reproductive hormones.

    Area of Science:

    • Reproductive Endocrinology
    • Gynecological Pharmacology

    Background:

    • Endometriosis is a condition characterized by the presence of endometrial-like tissue outside the uterus.
    • Danazol, a synthetic derivative of testosterone, is used to treat endometriosis by suppressing ovarian function.

    Purpose of the Study:

    • To investigate the hormonal changes induced by Danazol during a 6-month treatment course for endometriosis.
    • To assess the reversibility of Danazol's hormonal effects after treatment discontinuation.

    Main Methods:

    • Hormonal profiles (LH, FSH, estradiol, progesterone) were measured in patients with endometriosis over a 6-month Danazol treatment period.
    • Estradiol binding to endometrial cytosol was evaluated.
    • Hormone levels were reassessed in the months following Danazol discontinuation.

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    Main Results:

    • Plasma estradiol levels decreased significantly, remaining below 30 pg/ml after week 4 of therapy.
    • Progesterone levels were consistently low, resembling those of the follicular phase.
    • Luteinizing hormone (LH) remained unchanged, while follicle-stimulating hormone (FSH) was in the low-normal range.
    • Danazol did not displace estradiol bound by endometrial cytosol.
    • All measured hormone parameters returned to levels indicative of normal ovulatory cycles post-treatment.

    Conclusions:

    • Danazol effectively suppresses estradiol and progesterone, creating a hypoestrogenic, anovulatory state consistent with follicular phase hormonal milieu.
    • The hormonal effects of Danazol are reversible, with a return to normal ovulatory function after cessation of therapy.
    • Danazol's mechanism does not involve direct displacement of estradiol from endometrial cytosol binding sites.