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Sesquiterpene lactones from Centaurea thessala and Centaurea attica. Antifungal activity
H Skaltsa1, D Lazari, C Panagouleas
1Department of Pharmacognosy, School of Pharmacy, University of Athens, Greece. skaltsa@pharm.uoa.gr
Phytochemistry
|January 5, 2001
Abstract:
The aerial parts of Centaurea thessala ssp. drakiensis and C. attica ssp. attica afforded, in addition to several known sesquiterpene lactones, two new eudesmanolides, 4-epi-sonchucarpolide and its 8-(3-hydroxy-4-acetoxy-2-methylene-butanoyloxy) derivative and one new eudesmane derivative, named atticin. The in vitro antifungal activity of most compounds was tested against nine fungal species, using the micro-dilution method. All the compounds tested showed great antifungal activity.