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Benzylbenzoate and norlignan glucosides from Curculigo pilosa: structural analysis and in vitro vascular activity

G Palazzino1, C Galeffi, E Federici

  • 1Laboratorio di Chimica del Farmaco, Istituto Superiore di Sanità, Rome, Italy.

Phytochemistry
|January 5, 2001
PubMed

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Adrenergic agonists' structure-activity relationship (SAR) determines their selectivity and efficacy. These agonists comprise a phenylethylamine moiety with an aromatic ring and an ethylamine side chain.
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of the aromatic...