Related Experiment Video
Updated: May 9, 2026

06:51
Ovariectomy and 17β-estradiol Replacement in Rats and Mice: A Visual Demonstration
Published on: June 7, 2012
Oral contraceptives and changes in nutritional requirements
M Palmery1, A Saraceno, A Vaiarelli
1Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy. carlomagno@gmail.com
European Review for Medical and Pharmacological Sciences
|July 16, 2013
Summary
Oral contraceptives (OCs) can deplete essential nutrients like folic acid and certain vitamins and minerals. Supplementation may be a crucial first-line approach for women taking OCs to prevent deficiencies.
Area of Science:
- Nutritional Science
- Pharmacology
- Women's Health
Background:
- Oral contraceptives (OCs) are widely used by women, impacting physiological processes.
- Research indicates OCs influence nutritional needs and can lead to specific nutrient depletions.
- The World Health Organization highlights the clinical relevance of OC's effect on nutrient requirements.
Purpose of the Study:
- To investigate the impact of oral contraceptives on vitamin and mineral requirements.
- To identify key nutrients that may be depleted in women using OCs.
- To explore the role of dietary supplements in preventing nutrient deficiencies in OC users.
Main Methods:
- Review of existing research on oral contraceptives and nutrient levels.
- Analysis of studies comparing nutrient status in OC users versus non-users.
- Consideration of factors contributing to deficiencies, such as diet and malabsorption.
Main Results:
- Key nutrient depletions associated with OC use include folic acid, vitamins B2, B6, B12, C, E, and minerals magnesium, selenium, and zinc.
- Blood levels of these nutrients are often lower in women taking OCs.
- Inadequate diet, lifestyle, and malabsorption can exacerbate deficiencies.
Conclusions:
- Women using oral contraceptives may have increased requirements for specific vitamins and minerals.
- Dietary supplementation should be considered a primary strategy to prevent and manage nutrient deficiencies in this population.
- Clinicians should proactively address potential nutritional impacts of OC use.
More Related Videos
Related Concept Videos
Birth Control Methods
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although vasectomy...
Hormonal Regulation of the Menstrual Cycle
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
Hormonal Control of the Ovarian Cycle
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Intrauterine Drug Delivery Systems
Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
Hormonal Regulation
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
Hormonal Regulation
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.

