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Related Experiment Videos

Herpes simplex type 2 causing fulminant hepatic failure.

R J Fahy1, E Crouser, E R Pacht

  • 1Department of Internal Medicine, Ohio State University Medical Center, Columbus, USA.

Southern Medical Journal
|January 6, 2001
PubMed
Summary

Fulminant hepatic failure (FHF) from herpes simplex virus (HSV) is rare but deadly in immunocompetent individuals. Early diagnosis via liver biopsy is crucial for timely treatment of this treatable condition.

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Area of Science:

  • Hepatology
  • Virology
  • Infectious Diseases

Background:

  • Fulminant hepatic failure (FHF) is a rare but severe condition.
  • Herpes simplex virus (HSV) infection can cause FHF, even in immunocompetent individuals.
  • Diagnosis is challenging due to the lack of typical mucocutaneous lesions.

Observation:

  • The case involved an immunocompetent woman who succumbed to FHF.
  • Herpes simplex virus type 2 hepatitis was suspected but not definitively diagnosed before death.
  • Key clinical indicators included elevated transaminases, leukopenia, and low bilirubin.

Findings:

  • Herpes simplex virus hepatitis is a rare but treatable cause of FHF.
  • Prompt diagnosis is essential for effective therapeutic intervention.

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  • Liver biopsy, particularly transjugular liver biopsy, is vital for establishing the etiology of FHF.

    • Implications:

    • Transjugular liver biopsy offers a safe and effective method for diagnosing FHF causes.
    • This procedure can significantly influence the management of FHF.
    • Establishing transjugular liver biopsy as a standard diagnostic tool is recommended in specialized centers.