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Related Experiment Videos

Multifocal pattern electroretinogram does not demonstrate localised field defects in glaucoma.

A I Klistorner1, S L Graham, A Martins

  • 1Save Sight Institute, Department of Ophthalmology, Sydney University, Australia. sasha@eye.usyd.edu.au

Documenta Ophthalmologica. Advances in Ophthalmology
|January 6, 2001
PubMed
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Multifocal pattern electroretinography (PERG) can be recorded in healthy individuals. However, multifocal visual evoked potential (VEP) is more effective than PERG in identifying localized visual field defects in glaucoma patients.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Visual Electrophysiology

Background:

  • Glaucoma is a progressive optic neuropathy characterized by visual field loss.
  • Accurate detection of localized visual field defects is crucial for glaucoma management.
  • Multifocal electrophysiological techniques offer potential for detailed assessment of visual function.

Purpose of the Study:

  • To establish the feasibility of recording multifocal PERG in normal subjects.
  • To investigate alterations in multifocal PERG in glaucoma patients.
  • To compare the efficacy of multifocal PERG and multifocal VEP in identifying glaucomatous visual field defects.

Main Methods:

  • Multifocal PERGs were recorded from 19 visual field sites using a pseudo-random binary m-sequence.

Related Experiment Videos

  • Twenty normal and 15 glaucoma subjects participated in the study.
  • Multifocal pattern VEPs were also recorded in glaucoma patients with a cortically scaled stimulus.

    • Main Results:

    • A consistent second-order kernel signal was observed in multifocal PERG recordings.
    • PERG amplitude showed a decrease with age in normal individuals.
    • Glaucoma patients exhibited reduced PERG amplitude across the visual field, not correlating with scotoma location.
    • Multifocal VEP demonstrated localized signal reductions in all glaucoma cases, corresponding to scotoma areas.

    Conclusions:

    • Multifocal PERG is recordable in healthy individuals.
    • Multifocal PERG does not accurately reflect localized retinal ganglion cell loss in glaucoma.
    • Multifocal pattern VEP effectively identifies localized visual field defects in glaucoma, outperforming multifocal PERG for this purpose.