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Updated: Aug 2, 2026

The 6-hydroxydopamine Rat Model of Parkinson's Disease
Published on: October 27, 2021
Effects of amantadine on modification of dopamine dependent behaviours by molindone
B S Dhaware1, J J Balsara, N V Nandal
1Department of Pharmacology, Padmashree Dr. DY Patil Medical College for Women, Pimpri, Pune 411018.
Abstract:
Amantadine, a dopamine agonist is reported to act by releasing dopamine from the dopaminergic nerve terminals as an anti-Parkinsonian drug. In the present behavioural study in the rat, molindone-induced catalepsy and ptosis, which are dopamine dependent-behaviors are reversed by amantadine. Amantadine has also revered molindone-induced inhibition of traction response in mice. Our study indicates that amantadine, like other DA agonists, e.g. amphetamine and apomorphine can antagonize or even reverse the neuroleptic induced dopaminergic behaviors.
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