Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chiromorphology at the molecular level.

R Kuroda1

  • 1Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan. ckuroda@mail.ecc.u-tokyo.ac.jp

Enantiomer
|January 6, 2001
PubMed
Summary

Chirality, or shape handedness, is fundamental in biology. This study explores chirality induction in molecules, revealing insights into DNA-ligand interactions and enantioselective reactions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

KLF15 deficiency accelerates cartilage destruction in inflammatory arthritis.

Scandinavian journal of rheumatology·2026
Same author

Risk of Symptomatic Skeletal Events After Discontinuation of Long-term Denosumab in Patients With Bone Metastases: A Retrospective Cohort Study.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
Same author

Practical use of ultrasonography for a trigger wrist -  a case report.

Acta chirurgiae plasticae·2025
Same author

Rectangular tapered short stem excellently preserves proximal bone mineral density preservation than tapered wedge short stem.

Acta orthopaedica Belgica·2023
Same author

Clinical outcomes of absorbable plates (hydroxyapatite-poly-l-lactide composites) for phalangeal fractures - case reports.

Acta chirurgiae plasticae·2023
Same author

Gastrointestinal: A case of significant esophageal ulceration due to oral iron pill therapy.

Journal of gastroenterology and hepatology·2023

Area of Science:

  • Chemistry
  • Biology
  • Biophysics

Background:

  • Chiromorphology, the chirality of shape, is a fundamental property observed across all natural scales, from molecules to organisms.
  • Life on Earth relies on molecules with specific handedness, such as nucleic acids and proteins.

Purpose of the Study:

  • To explore chiromorphology across different scales and identify connections between them.
  • To review and present research on chirality induction and chiral discrimination.
  • To investigate the role of chirality in molecular interactions and reactions.

Main Methods:

  • Review of chiromorphology across molecular to organismal levels.
  • Experimental studies on chirality induction in solution and solid states.
  • Chiral discrimination studies in the solid state.
  • Solid-state Circular Dichroism (CD) spectroscopy.

Main Results:

  • Chirality induction by chiral compounds provides insights into DNA-ligand interactions.
  • Achiral molecules can adopt chiral conformations in the solid state, facilitating enantioselective reactions.
  • Solid-state specific chiral phenomena were successfully detected using CD spectroscopy.

Conclusions:

  • Chiromorphology is a unifying principle across biological organization.
  • Chirality induction and solid-state phenomena offer novel approaches to understanding molecular interactions and developing enantioselective processes.

Related Experiment Videos