Related Experiment Videos
Convenient synthesis of optically active 2,2,2-trifluoro-1-phenylethylamine
1Department of Chemistry, National Industrial Research Institute of Nagoya, Hirate-cho, Kita-ku, Nagoya 462-8510, Japan. ktykato@nirin.go.jp
Enantiomer
|January 6, 2001
Abstract:
Amination of aryl trifluoromethyl ketones with ammonium formate readily gave racemic 2,2,2-trifluoro-1-arylethylamines in good yields. Resolution of 2,2,2-trifluoro-1-phenylethylamine was carried out with the Pseudomonas fluorescens lipase via enantioselective alcoholysis of its chloroacetamide.