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ACE and alpha-adducin genotypes and renal disease progression
1CNR Centro Fisiologia Clinica e Unità Operativa di Nefrologia, Dialisi e Trapianto Renale, Reggio Calabria, Italy.
Abstract:
In the REIN study of non-diabetic proteinuric nephropathies, renal disease progression was independent of the angiotensin-converting enzyme (ACE) and alpha-adducin genotypes. However, the ACE genotype predicted the renoprotective effect of ACE inhibition. Subgroup analysis in patients with Berger disease showed a tendency (NS) for a faster progression in DD homozygotes.