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[Acute cholestatic hepatitis induced by propylthiouracil. Case report]
M B Parolin1, R W Lopes, J E Telles
1Serviço de Transplante Hepático e Serviço de Anatomia Patológica, Hospital de Clínicas da Universidade Federal do Paraná HC-UFPR.
Arquivos De Gastroenterologia
|January 6, 2001
Summary
Propylthiouracil can cause rare but severe liver injury in patients with hyperthyroidism. Prompt drug discontinuation led to symptom resolution and normalized liver tests in a teenage boy.
Area of Science:
- Hepatology
- Endocrinology
- Pharmacology
Background:
- Propylthiouracil is a common treatment for hyperthyroidism.
- Drug-induced liver injury (DILI) from propylthiouracil is uncommon but can be severe.
- This report details a specific case of DILI in a pediatric patient.
Observation:
- A 15-year-old boy developed acute cholestatic hepatitis while on propylthiouracil for hyperthyroidism.
- Other potential causes of liver disease, including viral, metabolic, and autoimmune factors, were ruled out.
- Liver biopsy results were consistent with drug-induced cholestatic hepatitis.
Findings:
- Discontinuation of propylthiouracil resulted in gradual symptom improvement.
- Liver biochemical tests returned to normal levels after stopping the medication.
- The case highlights the potential for severe hepatotoxicity despite the rarity of the condition.
Implications:
- Clinicians should consider propylthiouracil-induced hepatitis in patients with unexplained liver injury.
- Awareness of this rare side effect is crucial for patient safety.
- Monitoring liver function in patients treated with propylthiouracil is recommended.