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Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells
09:25

Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells

Published on: August 19, 2016

[Occurrence and susceptibility to antibiotics of Streptococcus pyogenes strains from purulent infections in soft

I Kania1, E Gospodarek, B Ulatowska

  • 1Katedry i Zakładu Mikrobiologii AM w Bydgoszczy.

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|January 6, 2001
PubMed

Insights

Streptococcus pyogenes from soft tissue infections showed resistance to MLSB antibiotics. However, all strains remained susceptible to penicillin, new quinolones, and glycopeptides, indicating effective treatment options.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Context:

  • Focuses on Streptococcus pyogenes, a significant pathogen in soft tissue infections.
  • Examines isolates from both hospital and ambulatory patients between 1996-1998.
  • Analyzes a large sample size (3665) including wound swabs, pus, and ulcer swabs.

Purpose:

  • To determine the occurrence and antimicrobial susceptibility of Streptococcus pyogenes in purulent soft tissue infections.
  • To identify resistance patterns, specifically Macrolide-Lincosamide-Streptogramin B (MLSB) resistance.
  • To evaluate the effectiveness of common antibiotics against these isolates.

Summary:

  • 3665 samples yielded Streptococcus pyogenes, predominantly from shank ulcers (38.8%).
  • Of 59 S. pyogenes strains analyzed, 10.2% exhibited MLSB resistance.
  • All tested strains demonstrated susceptibility to penicillin, new quinolones, and glycopeptides.

Impact:

  • Highlights the prevalence of S. pyogenes in soft tissue infections and identifies key sources.
  • Provides crucial data on emerging antimicrobial resistance, particularly MLSB resistance.
  • Confirms the continued efficacy of penicillin, new quinolones, and glycopeptides for treating these infections.

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