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Characterization of the novel allele HLA-B*4417: implications for bone marrow transplantation
H A Elsner1, G Schmitz, M Ballas
1Department of Transfusion Medicine, Hannover Medical School, Germany.
Tissue Antigens
|January 6, 2001
Abstract:
The identification of the novel allele HLA-B*4417, which was found in a blood donor of Caucasian origin, is described. In the sequence analysis the new allele differs from B*4402 by three nucleotides in exon 3. At the protein level, the new allele has two residue differences compared to B*4402. Due to substantial differences with other B*44 variants a possible mismatch may impair clinical outcome of bone marrow transplantation.