Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Surfing pathogens and the lessons learned for actin polymerization.

F Frischknecht1, M Way

  • 1Cell Biology and Biophysics Programme, European Molecular Biology Laboratory, Meyerhofstrabetae 1, 69117, Heidelberg, Germany.

Trends in Cell Biology
|January 9, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Baseline parameters for rotational thromboelastometry in healthy labouring women: a prospective observational study.

BJOG : an international journal of obstetrics and gynaecology·2020
Same author

Skin cancer multiplicity in lung transplant recipients: a prospective population-based study.

The British journal of dermatology·2019
Same author

Baseline parameters for rotational thromboelastometry (ROTEM®) in healthy pregnant Australian women: a comparison of labouring and non-labouring women at term.

International journal of obstetric anesthesia·2019
Same author

Baseline parameters for rotational thromboelastometry (ROTEM®) in healthy women undergoing elective caesarean delivery: a prospective observational study in Australia.

International journal of obstetric anesthesia·2019
Same author

Plasma observations during the Mars atmospheric "plume" event of March-April 2012.

Journal of geophysical research. Space physics·2018
Same author

Intentions and barriers to research activities among Australian and New Zealand anaesthetists: a Survey.

Anaesthesia and intensive care·2015
Same journal

Horizontal transfer of mitochondria in cancer: The physiology reborn in disease?

Trends in cell biology·2026
Same journal

Spindle errors: A stress test for epithelial robustness.

Trends in cell biology·2026
Same journal

Multicellular ecosystems: Linking cellular diversity to tissue function and disease.

Trends in cell biology·2026
Same journal

Orchestrating the signaling-bias at the protease-activated receptor, PAR1.

Trends in cell biology·2026
Same journal

Crashing by design: Utilizing DNA damage for MCC differentiation.

Trends in cell biology·2026
Same journal

The value of a shared lab: Our insights.

Trends in cell biology·2026
See all related articles

Pathogens like bacteria and vaccinia virus hijack actin polymerization for infection. Studying their manipulation of the actin cytoskeleton reveals insights into cell migration and pathogen control strategies.

Area of Science:

  • Microbiology
  • Cell Biology
  • Infectious Diseases

Background:

  • Many unrelated bacterial species and vaccinia virus utilize host cell actin polymerization to promote infection.
  • Understanding how pathogens manipulate the actin cytoskeleton offers insights into cellular processes like migration.

Purpose of the Study:

  • To review current knowledge on actin-based motility mechanisms used by pathogens.
  • To identify knowledge gaps regarding pathogen hijacking of the actin cytoskeleton.

Main Methods:

  • Literature review focusing on actin-based motility.
  • Analysis of mechanisms employed by Listeria, Shigella, and vaccinia.
  • Identification of further research areas concerning other pathogens.

Related Experiment Videos

Main Results:

  • Pathogens exploit actin polymerization for entry, intracellular movement, and host cell manipulation.
  • Studies reveal conserved and distinct strategies pathogens use to control actin dynamics.
  • Insights gained from model pathogens inform understanding of other bacterial and viral infections.

Conclusions:

  • Pathogen-driven actin dynamics provide a powerful model for studying fundamental cell biology.
  • Further research on pathogens like enteropathogenic Escherichia coli and Rickettsia is needed to fully understand actin hijacking.
  • Targeting pathogen-induced actin remodeling could offer novel therapeutic strategies.