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Updated: Jul 27, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Effects of stent design on side branch occlusion after coronary stent placement
1Department of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.
Insights
Stent-associated side branch occlusion (SBO) is not linked to stent type but rather to side branch ostial disease. Ostial disease is the primary predictor of SBO, impacting both immediate and long-term outcomes.
Area of Science:
- Cardiovascular Interventions
- Interventional Cardiology
- Biomedical Engineering
Background:
- Coronary stenting is a common procedure for treating atherosclerotic lesions.
- Side branch (SB) patency after stent implantation is crucial for long-term outcomes.
- Understanding factors influencing SB occlusion (SBO) is essential for optimizing interventional strategies.
Purpose of the Study:
- To evaluate the immediate and long-term patency of stent-associated side branches (SB).
- To compare the incidence of SBO across different stent designs (CrossFlex, NIR, GFX).
- To identify predictors of SBO following coronary stenting.
Main Methods:
- Retrospective analysis of 314 patients with 332 lesions undergoing stenting.
- Inclusion of 365 side branches (>1 mm) covered by coronary stents.
- Assessment of SBO rates and follow-up at 6 months, analyzing SB ostial disease and in-stent restenosis.
Main Results:
- Overall SBO rates were similar across CrossFlex (7.7%), NIR (10.5%), and GFX (8.8%) stents (P = NS).
- SB ostial disease was the sole independent predictor of SBO (OR 22.1, P < 0.001).
- At 6 months, 11 of 31 occluded SBs regained patency; delayed SBO was linked to ostial disease and restenosis.
Conclusions:
- SBO incidence is not significantly associated with specific stent designs.
- SB lesion morphology, particularly ostial disease, is the critical determinant of SBO.
- Ostial disease presence strongly predicts SBO and influences long-term SB patency after stenting.
Abstract:
This study was performed to assess the immediate and long-term patency of stent-associated side branches (SB) according to the types of stent. A total of 314 patients with 332 lesions (CrossFlex stent 86, NIR 100, GFX 146) had 365 SB (>1 mm) covered by coronary stents. Side branch occlusion (SBO) occurred in 7.7% of CrossFlex stent, in 10.5% of NIR stent and in 8.8% of GFX stent (P = NS). SBO primarily occurred in SB with ostial disease, and the presence of SB ostial disease was the only independent predictors of SBO after stenting (OR 22.1, 95% CI 9.47-51.49, P < 0.001). At 6 months follow-up, 11 of 31 SBO regained the patency, but the remaining SB had persistent SBO. Delayed SBO occurred in 8 SB, being associated with the presence of SB ostial disease and in-stent restenosis. In conclusions, SBO was not associated with the types of stent design, but with the SB lesion morphology.
