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Liposomes containing drug and cyclodextrin prepared by the one-step spray-drying method
N Skalko-Basnet1, Z Pavelic, M Becirevic-Lacan
1Department of Pharmaceutics, Faculty of Pharmacy and Biochemistry, University of Zagreb, A. Kovacica 1, Zagreb, Croatia. natasab61@hotmail.com
Drug Development and Industrial Pharmacy
|January 9, 2001
Summary
Spray-drying efficiently prepares liposomes with drugs and cyclodextrins (CDs). Direct spray-drying of lipids, drugs, and hydroxypropyl-beta-cyclodextrin (HP beta CD) yielded the most stable liposomes for drug delivery.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Materials Science
Background:
- Liposomes are versatile drug delivery vehicles.
- Spray-drying offers a scalable method for liposome preparation.
- Cyclodextrins enhance drug solubility and stability within liposomes.
Purpose of the Study:
- To develop a one-step spray-drying method for preparing drug-loaded liposomes.
- To characterize spray-dried liposomes containing metronidazole or verapamil with or without hydroxypropyl-beta-cyclodextrin (HP beta CD).
- To evaluate the impact of formulation and storage on liposome properties and serum stability.
Main Methods:
- One-step spray-drying of lipid, drug, and cyclodextrin mixtures.
- Characterization of liposomes for morphology, size distribution, and drug entrapment efficiency.
- Assessment of liposome serum stability after 24-hour incubation.
Main Results:
- Liposomal size was primarily influenced by the aqueous medium volume during hydration.
- No significant changes in size or entrapment were observed after 1 year of storage at 4°C.
- Liposomes prepared by direct spray-drying of lipid, drug, and HP beta CD exhibited superior serum stability.
Conclusions:
- The one-step spray-drying method is effective for producing stable, drug-loaded liposomes.
- Hydroxypropyl-beta-cyclodextrin incorporation enhances liposome stability.
- Spray-dried liposomes demonstrate potential for improved drug delivery applications.