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Activation of Xenopus Chk1 by mutagenesis of threonine-377

S X Wang1, W G Dunphy

  • 1Division of Biology 216-76, Howard Hughes Medical Institute, California Institute of Technology, 1200 East California Blvd., Pasadena, CA 91125, USA.

FEBS Letters
|January 11, 2001
PubMed

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In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
In vitro Mutagenesis01:16

In vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.