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Lysyl oxidase (LOX)-mediated remodeling of the extracellular matrix
Fernando Rodríguez-Pascual1, Marta Navarro-Gutiérrez1, Verónica Romero-Albillo1
1Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.
Abstract:
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross-link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders, and cancer.
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