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Updated: Aug 12, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
In vitro activity of linezolid against multiply resistant Gram-positive clinical isolates
E Cercenado1, F García-Garrote, E Bouza
1Servicio de Microbiología, Hospital General Universitario 'Gregorio Marañón', Dr Esquerdo 46, 28007 Madrid, Spain. fgarrote@efd.net
Abstract:
The in vitro activity of the oxazolidinone linezolid was compared with the activities of vancomycin and teicoplanin against 450 Gram-positive clinical isolates, including a variety of multiply resistant strains. Linezolid inhibited all microorganisms tested at < or = 4 mg/L, including methicillin- and teicoplanin-resistant staphylococci, glycopeptide-resistant enterococci, penicillin- and multiply resistant pneumococci and viridans streptococci, and erythromycin-resistant beta-haemolytic streptococci. The MIC(90) of linezolid for all isolates was 2 mg/L.
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