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Updated: Aug 12, 2026

Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy
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Evidence for a partially folded intermediate in alpha-synuclein fibril formation

V N Uversky1, J Li, A L Fink

  • 1Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA.

The Journal of Biological Chemistry
|January 22, 2001
PubMed
Summary

Investigating alpha-synuclein aggregation, this study reveals that changes in pH and temperature induce a partially folded intermediate. This intermediate is key to the formation of pathological fibrils in neurodegenerative diseases like Parkinson's disease.

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