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Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo
09:44

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Published on: June 2, 2019

Trimethylamine-N-oxide-induced folding of alpha-synuclein

V N Uversky1, J Li, A L Fink

  • 1Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA. uversky@hydrogen.ucsc.edu

FEBS Letters
|December 6, 2001
PubMed
Summary

Trimethylamine-N-oxide (TMAO) influences human alpha-synuclein structure and fibrillation. Moderate TMAO promotes intermediate folding and fibrillation, while higher concentrations induce helical structures and oligomer formation.

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