Epidermolysis bullosa acquisita with electron microscopical studies

Epidermolysis bullosa acquisita (EBA), one of the rare, scarring, nonhereditary, mechanobullous diseases, occurred in a 74-year-old woman. Clinical histological, and immunofluorescent findings are comparible with those previously reported in cases of EBA. To our knowledge, this is the first report of electron microscopical studies in EBA. Electron microscopy of "normal-looking" skin with EBA shows a noncellular, amorphous material on the dermal side of the basal lamina. Electron microscopy of slightly traumatized skin with EBA is very similar to that seen in dermolytic bullous dermatosis.