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Antimetabolites and cytotoxic drugs
1Section of Dermatology, Department of Medicine, University of Arizona College of Medicine, Tucson, Arizona, USA.
Dermatologic Clinics
|January 13, 2001
Abstract:
Mycophenolic mofetil, azathioprine, thioguanine, methotrexate, and cyclophosphamide were initially used for the treatment of malignancies. Because of their immunosuppressive activity, the range of diseases responsive to these medications has expanded to include various autoimmune-related diseases. Discussion includes a historical perspective of each medication, recent updates on responsive dermatologic conditions, dosages, monitoring guidelines, and medication expense.