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Synthesis and antiviral activity of novel methylene cyclopropyl nucleosides
1Department of Medicinal Chemistry, College of Pharmacy, Chonnam National University, Kwangju, Korea.
Archives of Pharmacal Research
|January 13, 2001
Abstract:
Novel exomethylene cyclopropyl nucleosides were synthesized as potential antiviral agents. The key intermediate 5 was synthesized in 4 steps, from Feists acid 1 and was condensed with purine derivatives by the SN2 type reaction to give some cyclopropyl nucleosides. The synthesized nucleosides did not showed any significant antiviral activity against HSV-1, HSV-2, HCMV, HIV-1, HIV-2, and HBV up to 100 microM.