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A novel synthetic methods for alpha-amino acids from allyl ethers via N-allylcarbamates
1Laboratory of Organomedicinal Chemistry, College of Pharmacy, Sungkyunkwan University, Suwon, Korea. yhjung@skku.ac.kr
Archives of Pharmacal Research
|January 13, 2001
Abstract:
Protected alpha-Phenyl glycine 17 and phenylalanine 18 and 19 have been synthesized through an efficient three-step sequence from the corresponding allyl ethers 5, 7, and 10. The key intermediate in this synthesis is the corresponding allylic amines prepared by reaction of allyl ethers with chlorosulfonyl isocyanate.