Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genetic Lingo01:11

Genetic Lingo

Overview
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autism and anaesthesia: a simple framework for everyday practice.

BJA education·2024
Same author

Avelumab in unresectable/metastatic, progressive, grade 2-3 neuroendocrine neoplasms (NENs): Combined results from NET-001 and NET-002 trials.

European journal of cancer (Oxford, England : 1990)·2022
Same author

Clustering of comorbidities and associated outcomes in people with osteoarthritis - A UK Clinical Practice Research Datalink study.

Osteoarthritis and cartilage·2022
Same author

Comparative efficacy and safety of acetaminophen, topical and oral non-steroidal anti-inflammatory drugs for knee osteoarthritis: evidence from a network meta-analysis of randomized controlled trials and real-world data.

Osteoarthritis and cartilage·2021
Same author

Synovitis and bone marrow lesions associate with symptoms and radiographic progression in hand osteoarthritis: a systematic review and meta-analysis of observational studies.

Osteoarthritis and cartilage·2021
Same author

A systematic review and network meta-analysis of second-line therapy in hepatocellular carcinoma.

Current oncology (Toronto, Ont.)·2020
Same journal

Effectiveness of a blended care intervention in physiotherapy with exercise and education for patients with hip or knee osteoarthritis (SmArt-E): a multicentre pragmatic randomized controlled trial.

Osteoarthritis and cartilage·2026
Same journal

Through the lens of light sheet, knee innervation shines.

Osteoarthritis and cartilage·2026
Same journal

Deep Learning-based Quantification of Knee Effusion-Synovitis Volume on MRI - Technique Development and Validation.

Osteoarthritis and cartilage·2026
Same journal

Mapping articular cartilage maturation across postnatal development by proteomics.

Osteoarthritis and cartilage·2026
Same journal

Effect of an Oral Complementary Medicine Combination for Symptomatic Knee Osteoarthritis: A Double-Blind, Randomized, Placebo-Controlled Trial.

Osteoarthritis and cartilage·2026
Same journal

Multimodal characterization of articular cartilage degeneration in the humeral head using Raman spectroscopy, biomechanics, and imaging.

Osteoarthritis and cartilage·2026
See all related articles

Related Experiment Video

Updated: Jun 18, 2026

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
07:32

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

Genetics of hand osteoarthritis.

M Doherty1

  • 1Academic Rheumatology, City Hospital, Nottingham, UK. michael.doherty@nottingham.ac.uk

Osteoarthritis and Cartilage
|January 13, 2001
PubMed
Summary
This summary is machine-generated.

Genetic factors significantly contribute to hand osteoarthritis (OA), with studies identifying potential gene associations on chromosome 2q. Further research into gene-gene and gene-environment interactions is crucial for understanding hand OA pathogenesis.

More Related Videos

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
06:06

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
08:52

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

Related Experiment Videos

Last Updated: Jun 18, 2026

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
07:32

Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

Published on: May 6, 2020

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
06:06

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
08:52

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness

Published on: March 18, 2022

Area of Science:

  • Genetics
  • Rheumatology
  • Epidemiology

Background:

  • Epidemiological studies strongly suggest a hereditary component in hand osteoarthritis (OA).
  • Evidence includes higher concordance rates in monozygotic twins and increased risk in first-degree relatives of affected individuals.
  • Genetic factors are estimated to explain up to 59% of the variance in hand OA.

Purpose of the Study:

  • To identify specific genes involved in the pathogenesis of hand osteoarthritis.
  • To address challenges in gene association studies for complex polygenic conditions like OA.

Main Methods:

  • Utilized association studies in affected sibling pairs and nuclear families.
  • Employed candidate gene screening, genome-wide screening, and transmission disequilibrium testing.
  • Investigated potential associations with genes like COL2A1 and chromosomal regions.

Main Results:

  • No significant association was found with the COL2A1 gene, which is implicated in rare monogenic OA syndromes.
  • Preliminary evidence suggests possible genetic associations on chromosome 2q, though not yet isolated.
  • Challenges in case definition, phenotype expression timing, and environmental factors complicate gene association studies.

Conclusions:

  • Ongoing genetic research, including gene-gene and gene-environment interaction studies, is essential for understanding hand OA.
  • These studies are expected to provide significant, potentially novel insights into the mechanisms underlying hand OA development.