Related Experiment Video
Updated: Aug 9, 2026
Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
Published on: March 18, 2022
Associations between deep learning-derived infrapatellar fat pad volume on MRI with knee cartilage thickness and
Adrian A Marth1, Felix Liu2, Gabby B Joseph2
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA; Department of Radiology, Balgrist University Hospital, Zurich, Switzerland; Faculty of Medicine, University of Zurich, Zurich, Switzerland.
Objective:
To investigate associations between infrapatellar fat pad volume (IPFPVol) measured on MRI with knee cartilage thickness and imaging features of knee osteoarthritis.
Design:
This cross-sectional study used baseline data from the Osteoarthritis Initiative. IPFPVol was quantified using a deep learning algorithm for automatic volumetric IPFP segmentation. Outcomes by subregion included knee cartilage thickness in the lateral tibia (LT), medial tibia (MT), lateral femur (LF), medial femur (MF), and patella, along with Whole-Organ Magnetic Resonance Imaging Score (WORMS) scores for cartilage, bone marrow edema-like lesions (BMELL), and menisci across the same subregions and the trochlea. Linear regression models included an interaction term between IPFPVol and subregion. When interactions were significant, subregion-specific associations were estimated. Models were adjusted for relevant confounders.
Results:
A total of 4257 participants were included in the final analysis. Significant interactions between IPFPVol and subregion were observed for cartilage thickness and WORMS scores (all p<0.001). Larger IPFPVol was associated with greater cartilage thickness in the patella (β = 0.011 mm per cm³; 95% CI, 0.006-0.016) and LT (β = 0.015 mm per cm³; 95% CI, 0.010-0.019). For WORMS, larger IPFPVol was associated with lower cartilage lesion scores in the patella (β = -0.036 points per cm³; 95% CI, -0.061 to -0.010), LF (β = -0.058 points per cm³; 95% CI, -0.076 to -0.039), and LT (β = -0.079 points per cm³; 95% CI, -0.099 to -0.060), along with lower BMELL scores in the LT (β = -0.027 points per cm³; 95% CI, -0.036 to -0.018) and lower lateral meniscus scores (β = -0.054 points per cm³; 95% CI, -0.070 to -0.037).
Conclusions:
Larger IPFPVol was associated with greater patellofemoral cartilage thickness and less severe osteoarthritis features in the patellofemoral and lateral tibiofemoral joint. These findings highlight the subregion-specific relationship between IPFP volume, knee cartilage thickness and imaging features of osteoarthritis.
