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Induction of endothelial-leukocyte interaction by interferon-gamma requires coactivation of nuclear factor-kappaB
R De Caterina1, T Bourcier, U Laufs
1Vascular Medicine Unit, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Arteriosclerosis, Thrombosis, and Vascular Biology
|February 7, 2001
Abstract:
To determine whether nuclear factor (NF)-kappaB is necessary to confer endothelial cell responsiveness to interferon (INF)-gamma in terms of vascular cell adhesion molecule (VCAM)-1 expression and leukocyte adhesion, human endothelial cells were treated with IFN-gamma in the presence of low concentrations (LCs) of interleukin (IL)-1alpha (