Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Two hits revisited again.

I P Tomlinson1, R Roylance, R S Houlston

  • 1Molecular and Population Genetics Laboratory, Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK. i.tomlinson@icrf.icnet.uk

Journal of Medical Genetics
|February 7, 2001
PubMed
Summary

The "two hit hypothesis" for tumor suppressor genes needs updating due to new genetic data. Recent studies reveal complexities and gaps in our understanding, prompting a re-evaluation of cancer development models.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Final analysis of the ALTTO trial: adjuvant trastuzumab in sequence or in combination with lapatinib in patients with HER2-positive early breast cancer [BIG 2-06/NCCTG N063D (Alliance)].

ESMO open·2024
Same author

Expert UK consensus on the definition of high risk of recurrence in HER2-negative early breast cancer: A modified Delphi panel.

Breast (Edinburgh, Scotland)·2023
Same author

Analysis of rare disruptive germline mutations in 2135 enriched BRCA-negative breast cancers excludes additional high-impact susceptibility genes.

Annals of oncology : official journal of the European Society for Medical Oncology·2022
Same author

A Multicentre Retrospective Study of Fulvestrant Use and Efficacy in Advanced/Metastatic Breast Cancer.

Clinical oncology (Royal College of Radiologists (Great Britain))·2022
Same author

Correction: Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHV<sup>mut</sup> and IgHV<sup>unmut</sup> subgroups.

Leukemia·2019
Same author

Runs of homozygosity and testicular cancer risk.

Andrology·2019

Area of Science:

  • Genetics
  • Cancer Biology
  • Molecular Oncology

Background:

  • The
  • two hit hypothesis
  • has long guided cancer research.
  • Accumulated genetic data reveals significant gaps in this model.
  • Tumor suppressor gene mutations are central to cancer development.

Purpose of the Study:

  • To critically evaluate the current
  • two hit hypothesis
  • in light of new genetic and functional findings.
  • To identify limitations and areas requiring revision in cancer genetics models.
  • To explore emerging questions regarding tumor suppressor gene function in tumorigenesis.

Main Methods:

  • Review of extensive genetic data on tumor suppressor loci.
  • Analysis of recent genetic and functional studies.
  • Discussion of key questions and inconsistencies in the
  • two hit hypothesis
  • .

Main Results:

  • Significant knowledge gaps exist despite extensive genetic data.
  • The validity of applying Mendelian syndrome data to sporadic cancers is questioned.
  • The mechanisms and frequency of allelic loss require further investigation.

Conclusions:

  • The
  • two hit hypothesis
  • is not static but an evolving model.
  • New data necessitates an updated understanding of tumor suppressor gene roles.
  • Incorporating factors like mismatch repair and methylator phenotype is crucial.

Related Experiment Videos