The Chinese hamster dihydrofolate reductase replication origin beta is active at multiple ectopic chromosomal

A L Altman1, E Fanning

  • 1Department of Molecular Biology and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37232-6838, USA.

Summary

Researchers identified key DNA sequences controlling mammalian DNA replication. A specific fragment from the dihydrofolate reductase (DHFR) origin beta (ori-beta) region directs DNA replication initiation.

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