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Related Experiment Videos

Convex Arrhenius plots and their interpretation.

D Truhlar1, A Kohen

  • 1Department of Chemistry and Supercomputer Institute, University of Minnesota, Minneapolis, MN 55455-0431, USA. truhlar@umn.edu

Proceedings of the National Academy of Sciences of the United States of America
|February 7, 2001
PubMed
Summary

Convex Arrhenius plots in enzyme reactions are rare. Analysis reveals the rate coefficient decreases with energy, constraining microscopic models for these unique kinetics.

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Area of Science:

  • Chemical Kinetics
  • Biochemistry
  • Physical Chemistry

Background:

  • Enzyme-catalyzed reactions
  • Arrhenius plots
  • Activation energy models

Purpose of the Study:

  • Investigate rare convex Arrhenius plots in enzyme kinetics
  • Apply Tolman's interpretation of activation energy
  • Establish model-independent constraints for reaction mechanisms

Main Methods:

  • Analysis of experimental data on enzyme-catalyzed reactions
  • Theoretical interpretation using activation energy concepts
  • Comparison with existing kinetic models

Main Results:

  • Identified convex Arrhenius plots as rare but significant

Related Experiment Videos

  • Demonstrated decreasing microcanonical rate coefficient with energy
  • Established a fundamental constraint on microscopic models

    • Conclusions:

    • Convex Arrhenius plots necessitate a decreasing rate coefficient with energy
    • Tolman's interpretation provides a universal constraint
    • Findings applicable to enzyme mechanisms and broader kinetics