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Ischemic colitis during treatment with alosetron
D Friedel1, R Thomas, R S Fisher
1Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania, USA. dfriedel@astro.temple.edu
Gastroenterology
|February 13, 2001
Summary
Alosetron, a treatment for Irritable Bowel Syndrome (IBS), can cause ischemic colitis. This case study shows symptoms resolved after discontinuing the medication, highlighting potential risks.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Irritable bowel syndrome (IBS) is a common gastrointestinal disorder.
- Alosetron is a serotonin antagonist approved for diarrhea-predominant IBS.
- Significant side effects, including ischemic colitis, have been reported with alosetron.
Observation:
- A case of ischemic colitis in a male IBS patient treated with alosetron is presented.
- Clinical, endoscopic, and pathological findings suggested ischemia.
- Symptoms correlated with alosetron use and resolved upon discontinuation.
Findings:
- The patient experienced ischemic colitis during alosetron treatment.
- Discontinuation of alosetron led to symptom resolution.
- Endoscopic and pathological evidence confirmed the resolution of colitis.
Implications:
- Alosetron, while effective for IBS, carries a risk of serious side effects like ischemic colitis.
- Physicians should carefully consider the risks and benefits of alosetron.
- Monitoring for ischemic colitis in patients using alosetron is crucial.
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