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Related Experiment Videos

Salmonella: a model for bacterial pathogenesis.

M E Ohl1, S I Miller

  • 1Department of Medicine, Division of Infectious Diseases, University of Washington, 1959 NE Pacific Street, Seattle, Washington 98195, USA. millersi@u.washington.edu

Annual Review of Medicine
|February 13, 2001
PubMed
Summary
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Salmonella bacteria cause illness by evading the host immune system and invading cells. Different Salmonella serotypes cause gastroenteritis or enteric fever through distinct pathogenic strategies.

Area of Science:

  • Microbiology
  • Bacterial Pathogenesis
  • Immunology

Background:

  • Salmonellae are gram-negative bacteria responsible for gastroenteritis and enteric fever.
  • Bacterial virulence relies on coordinated expression of virulence factors to overcome host defenses.
  • Salmonella invasion of intestinal epithelial cells is a conserved pathogenic mechanism.

Purpose of the Study:

  • To review the molecular mechanisms underlying Salmonella virulence.
  • To highlight general themes in bacterial pathogenesis using Salmonella as a model.
  • To differentiate virulence strategies of gastroenteritis-causing versus enteric fever-causing Salmonella serotypes.

Main Methods:

  • Literature review of Salmonella pathogenesis research.
  • Analysis of molecular mechanisms of bacterial invasion and immune evasion.

Related Experiment Videos

  • Comparison of strategies employed by different Salmonella serotypes.

    • Main Results:

    • Salmonella invasion is mediated by inducing its own uptake into host cells.
    • Gastroenteritis-associated Salmonella induce intestinal inflammation and secretion.
    • Enteric fever-associated Salmonella survive within host mononuclear phagocytes for systemic infection.

    Conclusions:

    • Salmonella employs diverse virulence strategies to establish infection.
    • Understanding Salmonella pathogenesis provides insights into general bacterial disease mechanisms.
    • Targeting Salmonella virulence factors offers potential therapeutic avenues.