Intracerebral microdialysis and its clinical application: a review

In vivo intracerebral microdialysis is an important neurochemical technique that has been used extensively in the experimental setting. Relatively recently, techniques have been developed to utilize this method in human subjects. The past decade has seen the advent of clinical investigations utilizing in vivo microdialysis in a number of neuropathological states. This review summarizes the principles of in vivo microdialysis techniques, as applied to humans, while discussing the significance of recent investigations for future clinical development.