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Related Experiment Videos

Dermopathic changes in hypozincemia.

N N Abou-Mourad, F S Farah, D Steel

    Archives of Dermatology
    |August 1, 1979
    PubMed
    Summary

    Severe hypozincemia (low zinc levels) in patients on parenteral nutrition caused skin lesions and hair loss. Zinc sulfate replacement resolved these symptoms, highlighting the importance of zinc in gastrointestinal health.

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    Area of Science:

    • Gastroenterology and Nutritional Science

    Background:

    • Total parenteral nutrition (TPN) is a critical intervention for patients with chronic gastrointestinal diseases.
    • TPN regimens, particularly those with concentrated dextrose and L-amino acids, require careful monitoring for potential nutrient deficiencies.

    Observation:

    • Seven patients receiving TPN for debilitating gastrointestinal disease developed severe hypozincemia (serum zinc < 60 µg/dL).
    • Clinical manifestations included characteristic seborrheic dermatitis-like skin lesions and alopecia, concentrated in sebaceous gland-rich areas.
    • Hyperkeratotic lesions were observed on extensor surfaces of major joints.

    Findings:

    • Hypozincemia was directly linked to the development of specific dermatological symptoms and hair loss in TPN patients.
    • Restoration of serum zinc levels above 60 µg/dL through zinc sulfate supplementation led to the complete resolution of skin lesions and alopecia.

    Implications:

    • This study underscores the critical role of adequate zinc levels in maintaining skin integrity and hair health.
    • It highlights the need for vigilant zinc monitoring and appropriate supplementation in patients undergoing long-term parenteral nutrition.
    • The findings suggest a potential mechanism linking zinc deficiency to specific dermatological conditions observed in TPN-dependent individuals.

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