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Related Experiment Videos

Thiotepa-induced leukoderma.

D J Harben, P H Cooper, O G Rodman

    Archives of Dermatology
    |August 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Thiotepa ophthalmic solution caused periorbital depigmentation in a patient. Melanocytes were absent in the affected skin, highlighting drug-induced skin changes.

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    Area of Science:

    • Dermatology
    • Ophthalmology

    Background:

    • Thiotepa is an alkylating agent used postoperatively.
    • It was applied as an ophthalmic solution to prevent pterygium revascularization.

    Observation:

    • A black male developed periorbital depigmentation six months after thiotepa application.
    • Microscopic examination revealed an absence of melanocytes in the depigmented region.

    Findings:

    • The case suggests thiotepa can induce localized cutaneous depigmentation.
    • Histopathology confirmed melanocyte loss as the cause of depigmentation.

    Implications:

    • This adds thiotepa to the growing list of chemicals causing skin depigmentation.
    • Patient history is crucial for diagnosing vitiligo-like conditions potentially caused by medications.