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Cell-cycle-dependent translational control.

S Pyronnet1, N Sonenberg

  • 1Department of Biochemistry and McGill Cancer Center, 3655 promenade Sir William Osler, McGill University, Montréal, H3G 1Y6, Québec, Canada.

Current Opinion in Genetics & Development
|February 13, 2001
PubMed
Summary
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Translation control in eukaryotes primarily happens during initiation. Mammalian translation rates are high in G1 phase but decrease during mitosis, linked to cell cycle-modulated translation initiation factors.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Eukaryotic translation is primarily regulated at the initiation step.
  • Translation rates exhibit cell cycle-dependent variations in mammalian cells.
  • Canonical translation initiation factors play a crucial role in regulating protein synthesis.

Purpose of the Study:

  • To investigate the regulation of translation during the cell cycle in mammals.
  • To understand the role of translation initiation factors in cell cycle-dependent translation control.

Main Methods:

  • Analysis of translation rates across different cell cycle phases.
  • Assessing the activity of key translation initiation factors during the cell cycle.

Main Results:

Related Experiment Videos

  • Mammalian translation rates are robust during the G1 phase.
  • Translation rates are significantly lower during mitosis.
  • The activity of translation initiation factors is modulated throughout the cell cycle.

Conclusions:

  • Cell cycle progression influences global translation rates in mammalian cells.
  • Modulation of translation initiation factor activity is a key mechanism for cell cycle-dependent translation regulation.