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CD1 expression is differentially regulated by microglia, macrophages and T cells in the central nervous system upon
U Busshoff1, A Hein, A Iglesias
1Department of Neurobiology, Interdisziplinäres Zentrum für Neurowissenschaften, University of Heidelberg, INF 364, 69120, Heidelberg, Germany.
Abstract:
Expression of CD1 by microglia, macrophages and T cells was investigated ex vivo. In the healthy central nervous system (CNS), resident microglia, macrophages and T cells express levels of CD1 significantly lower than that expressed by splenic macrophages and T cells. During experimental autoimmune encephalomyelitis (EAE), CD1 expression by microglia and the number of CD1+ microglia increase. Macrophages and T cells strongly upregulate CD1 expression in the CNS, but not in the spleen. Whereas the function of CD1 expressed by T cells remains unclear, the expression by microglia and macrophages provides the CNS with a (glyco)lipidic-presenting molecule in an inflammatory and demyelinating environment.