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Multicentric reference values for some quantities measured with the Elecsys 2010 analyser.

X Fuentes-Arderiu1, M Ferrer-Masferrer, J M González-Alba

  • 1Servei de Bioquímica Clínica, Ciutat Sanitària i Universitària de Bellvitge, L'Hopitalet de Llobregat, Catalonia, Spain. xfa@csub.scs.es

Clinica Chimica Acta; International Journal of Clinical Chemistry
|February 13, 2001
PubMed
Summary

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Clinical labs in Spain collaborated to establish reference values for thyrotropin, thyroid hormones, cobalamins, and folates. This multicentric approach, using the Elecsys 2010 analyser, provides a model for industry-laboratory partnerships in diagnostics.

Area of Science:

  • Clinical Chemistry
  • Laboratory Medicine
  • In Vitro Diagnostics

Background:

  • Establishing reliable reference values is crucial for accurate clinical laboratory testing.
  • Previous efforts lacked standardized multicentric approaches for key analytes.

Purpose of the Study:

  • To develop multicentric reference limits for thyrotropin, non-protein bound thyroxine, triiodothyronine, cobalamines, and folates.
  • To evaluate a collaborative model between clinical laboratories and diagnostic industry suppliers.

Main Methods:

  • A multicentric study involving several Spanish clinical laboratories.
  • Utilized the Elecsys 2010 analyser for all measurements.
  • Reference limits were estimated based on pooled data, adhering to International Federation of Clinical Chemistry guidelines.

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Main Results:

  • Successfully generated multicentric reference limits for the specified analytes.
  • Demonstrated the feasibility of a collaborative virtual laboratory approach.
  • The pooled reference values represent a blend from individual laboratory findings.

Conclusions:

  • The study established a successful model for inter-laboratory cooperation in producing diagnostic reference values.
  • This collaborative effort, supported by industry, enhances the reliability of clinical laboratory results.
  • The findings provide a valuable framework for future multicentric reference value studies.