Related Experiment Video
Updated: Oct 9, 2026

Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
Published on: March 26, 2019
Endothelial cells and the pathogenesis of lepromatous neuritis:insights from the armadillo model
1Research Pathology Department, National Hansen's Disease Program at LSU, Baton Rouge, LA 70894, USA. dscoll1@lsu.edu
Abstract:
Selective infection of peripheral nerves is a unique property of Mycobacterium leprae that results in serious injury, but its basis is unexplained. Recent evidence from infected armadillos suggests that endothelial cells of peripheral nerve vasculature may be the gatekeepers by which M. leprae infects nerves. The pathogenesis of neuropathy in leprosy may thus entail a dynamic sequence of adhesion, immunologic, and inflammatory processes involving peripheral nerve endothelial cells.

