Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Embryo quality and developmental potential is compromised by age.

S Ziebe1, A Loft, J H Petersen

  • 1The Fertility Clinic, The Juliane Marie Center, Rigshospitalet, University of Copenhagen, Denmark.

Acta Obstetricia Et Gynecologica Scandinavica
|February 13, 2001
PubMed
Summary

Female age significantly impacts fertility outcomes in assisted reproductive technology (ART). Fertility decline begins in the late twenties, affecting oocyte quality, embryo development, and pregnancy rates.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Subject injury and police use of force in mental health crises.

International journal of law and psychiatry·2025
Same author

Associations between mental illness, TB risk and migrant status.

IJTLD open·2024
Same author

Enhancing casein micelle dissociation in diluted skim milk systems using combined processing techniques.

Journal of dairy science·2024
Same author

An integrated biological effects assessment of the discharge water into the Sunndalsfjord from an aluminium smelter.

The Science of the total environment·2023
Same author

Unsuccessful treatment of chronic norovirus infection with enteral immunoglobulin in patients with common variable immunodeficiency, case report.

IDCases·2023
Same author

The clinical task force: Improving quality of medical students' internship.

Heliyon·2023

Area of Science:

  • Reproductive Medicine
  • In Vitro Fertilization (IVF)
  • Human Reproduction

Background:

  • Female age is a critical factor influencing reproductive success.
  • General assumptions often place the onset of significant age-related fertility decline in the mid-thirties.

Purpose of the Study:

  • To retrospectively evaluate the effect of female age on oocyte and embryo quality and developmental potential within an ART program.
  • To determine the specific age at which fertility decline becomes statistically significant.

Main Methods:

  • Analysis of 878 in vitro fertilization (IVF) cycles with uniform embryo quality and developmental stage at transfer.
  • Inclusion of single, dual, and triple embryo transfer cycles.

Main Results:

Related Experiment Videos

  • Significant decrease in oocyte recovery and cleavage rates with advancing age.
  • No significant increase in embryo fragmentation, but a 3% annual increase in fragmentation odds.
  • Reduced implantation and ongoing pregnancy rates, alongside increased abortion rates, correlated with maternal age.
  • A notable decline in ongoing pregnancy rates by approximately 1.5% per year.

Conclusions:

  • Maternal age negatively impacts fertility throughout a woman's reproductive lifespan.
  • The age-related decline in fertility commences earlier than commonly believed, potentially starting in the late twenties.