Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Is Chordin a morphogen?

J Hama1, D C Weinstein

  • 1Department of Pharmacology, Mount Sinai School of Medicine, New York, New York, USA.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|February 13, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SNT-1/FRS2alpha physically interacts with Laloo and mediates mesoderm induction by fibroblast growth factor.

Mechanisms of development·2001
Same author

Regulation of Laloo by the Xenopus C-terminal Src kinase (Xcsk) during early vertebrate development.

Oncogene·2001
Same author

Src family kinase function during early Xenopus development.

Developmental dynamics : an official publication of the American Association of Anatomists·2001
Same author

Neural induction.

Annual review of cell and developmental biology·1999
Same author

Alpha1-adrenergic stimulation induced hypertrophy in protein kinase C down-regulated cultured cardiac myocytes.

Clinical and experimental hypertension (New York, N.Y. : 1993)·1999
Same author

FGF-mediated mesoderm induction involves the Src-family kinase Laloo.

Nature·1998
Same journal

AI in Genomics: From Variant Calling to Multi-Omics Integration.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Rethinking One Health: Microbial Foundations for Ecological Governance.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Biobanked Liver Organoids: A Roadmap for Precision Hepatology.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

The Temporal Architecture of Human Cells: Organelle Clocks and Distributed Circadian Time.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Opposing Activity at the Apical Surface: An Antagonistic Collaboration Between Crumbs and Myosin II Determines Organ Shape.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
Same journal

Hidden Fungal DNA Structures May Shape Sequencing Outcomes.

BioEssays : news and reviews in molecular, cellular and developmental biology·2026
See all related articles

This study investigates if Chordin acts as a long-range morphogen in amphibian embryos. Findings suggest Chordin establishes a functional gradient of Bone Morphogenetic Protein (BMP) activity, crucial for embryonic patterning.

Area of Science:

  • Developmental biology
  • Embryology
  • Molecular biology

Background:

  • Morphogen gradients are key to regional specification in early embryos.
  • Dorsoventral patterning in vertebrate embryos involves Bone Morphogenetic Proteins (BMPs) and inhibitors like Chordin.

Purpose of the Study:

  • To explore Chordin's role as a long-range factor in amphibian gastrula embryos.
  • To understand how Chordin establishes a functional gradient of BMP activity.

Main Methods:

  • The study by Blitz and colleagues investigated the function of Chordin.
  • Analysis focused on its role in establishing BMP activity gradients.

Main Results:

  • Evidence suggests Chordin functions as a long-range factor.

Related Experiment Videos

  • This action is critical for creating a functional gradient of BMP activity.

    • Conclusions:

    • Chordin plays a significant role in dorsoventral patterning during amphibian gastrulation.
    • Its long-range activity is essential for establishing the BMP activity gradient that specifies cell fates.