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Circumdatin G, a new alkaloid from the fungus Aspergillus ochraceus
J Dai1, B K Carté, P J Sidebottom
1Centre for Natural Product Research, Institute of Molecular and Cell Biology, 59A Science Park Drive, The Fleming, Singapore Science Park, Singapore.
Journal of Natural Products
|February 15, 2001
Abstract:
The crude extract of the broth of Aspergillus ochraceus was found to inhibit the final stage of polyprotein processing during hepatitis C virus replication. Bioassay-guided fractionation led to the isolation of the known compound mellein as the active component of the extract. Also isolated were circumdatin F and a new alkaloid, circumdatin G. The structure of circumdatin G was determined by spectroscopic analysis.