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Updated: Oct 9, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
Stress, medical illness, and depression
L M Slimmer1, J M Lyness, E D Caine
1Department of Psychiatry, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. Lisa_Slimmer@urmc.rochester.edu
Abstract:
In this review, we present potential pathways through which medical illness may act as a stress-related catalyst of major depression. We will consider available evidence and discuss biological, psychological, and psychosocial theories, individually and in their interplay, in an attempt to better understand the potential roles of stress in mediating the relationships between medical illness and mood disorder. We will use the specific example of major depression occurring after acute myocardial infarction to illustrate the application of our theoretical framework.
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