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Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
Published on: January 7, 2019
Opposing regulation of B cell receptor-induced activation of mitogen-activated protein kinases by CD45
M Ogimoto1, Y Arimura, T Katagiri
1Department of Immunology and Signal Transduction, Tokyo Metropolitan Institute for Neuroscience/Medical Research, 2-6 Musashidai, Fuchu, Tokyo 183-8526, Japan.
Abstract:
In this study, we examined the contribution made by CD45 to B cell antigen receptor (BCR)-induced activation of mitogen-activated protein kinase (MAPK) family members. We found that CD45 negatively regulated BCR-induced c-Jun NH(2)-terminal kinase (JNK) and p38 activation in immature WEHI-231 cells, whereas in mature BAL-17 cells, CD45 positively regulated JNK and p38 activation and negatively regulated extracellular signal-regulated kinase activity. Furthermore, cooperative action of JNK and p38 dictated BCR-induced inhibition of growth. Thus, CD45 appears to differentially regulate BCR-induced activation of MAPK members, and can exert opposing effects on JNK and p38 in different cellular milieu, controlling the B cell fate.
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